The Endocannabinoid System
A network of signals, receptors and enzymes found throughout the body that helps maintain internal balance, known as homeostasis.
Inside the signal
A tiny message. A connected system.
Move through four steps to see how an ECS signal works.
Simplified illustration · not a dose or health simulator
CB1 is especially abundant in the nervous system, where it helps regulate communication between nerve cells.
Make a messenger
When needed, a cell produces endocannabinoids such as anandamide or 2-AG. These are made by your body — no cannabis is needed.
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Endocannabinoids
Molecules your body makes on its own, mainly anandamide (AEA) and 2-AG. They are produced on demand and act as short-lived messengers.
Receptors
CB1 receptors are found mostly in the brain and nervous system. CB2 receptors are found mostly in immune cells and peripheral tissue.
Enzymes
FAAH and MAGL break endocannabinoids down once they've done their job, keeping the signal tightly regulated.
What it helps regulate
The ECS is involved in many everyday processes. Researchers continue to study how it works and how plant compounds such as cannabinoids interact with it.
How plant cannabinoids fit in
Plant cannabinoids can interact with the ECS without being the same molecules as your body's messengers. THC activates CB1 and CB2 receptors; CBD has low affinity for those receptors and acts through multiple pathways. These interactions are complex and do not imply that cannabis improves every process the ECS regulates.
A little brain spark
Does your body need cannabis to make endocannabinoids?
For educational purposes only. This content is not medical advice and has not been evaluated by the FDA.